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Cardiovascular Changes in Living Kidney Donors After 12 Months

The data continues to mount.


“We hypothesized that the reduction in GFR in living kidney donors is associated with increased left ventricular mass, impaired left ventricular function, and increased aortic stiffness.”

” At 12 months, the decrease in isotopic GFR in donors was -30±12 . In donors compared with controls, there were significant increases in left ventricular mass (+7±10 versus -3±8 g/mL) and mass:volume ratio (+0.06±0.12 versus -0.01±0.09 g/mL), whereas aortic distensibility (-0.29±1.38 versus +0.28±0.79×10-3 mmHg-1) and global circumferential strain decreased (-1.1±3.8 versus +0.4±2.4%). Donors had greater risks of developing detectable highly sensitive troponin T and microalbuminuria. Serum uric acid, parathyroid hormone, fibroblast growth factor-23, and high-sensitivity C-reactive protein all increased significantly. ”

These findings suggest that reduced GFR should be regarded as an independent causative cardiovascular risk factor.


Moody, W., Ferro, C., Edwards, N., Chue, C., Lin, E., Taylor, R., Cockwell, P., Steeds, R., & Townend, J. (2016). Cardiovascular Effects of Unilateral Nephrectomy in Living Kidney Donors Hypertension DOI: 10.1161/HYPERTENSIONAHA.115.06608

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