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Living Donor Protections Living Donor Research Living Donor Risks

Latest KDIGO Guidelines for Living Kidney Donors

Before reading the linked article, remember that many aspects of living donor evaluation, care and consequences have never been adequately documented or studied. So, those very real issues won’t be included or considered (the authors admit as much in their abstract), which results in yet *another* incomplete and tragically flawed guidance document.

 

Why bother posting it? Well, because it’s important to see if any progress has been made at all. Plus, prospective living donors should be aware of what to expect from their transplant centers.

Here you go: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540357/

 

Keep in mind that transplant centers, essentially, make up their own rules in terms of what is, and isn’t, an acceptable living donor. Theoretically, a potential LKD could receive a much higher standard of care at one center as opposed to another. Frankly, I find that scary as hell.

 

 

Categories
Informed Consent Living Donor Research Living Donor Risks

Pregnancy Post-Donation Includes Risk

Per a study from March 2016:

 

“A concern for donation-related risk was recently confirmed in an 11-year cohort study of 85 female donors and 510 healthy non-donors who were carefully matched on baseline risk factors. Donors were 2.4 times more likely to be diagnosed with gestational hypertension or preeclampsia compared with healthy non-donors.”

The confirmation above refers to prior studies that have also come to this same conclusion. Search the blog for other pregnancy related posts.

 

 

Sontrop, J., & Garg, A. (2016). Considerations for Living Kidney Donation Among Women of Childbearing Age: Evidence from Recent Studies Current Transplantation Reports, 3 (1), 10-14 DOI: 10.1007/s40472-016-0082-0

Categories
Ethical Considerations Informed Consent Living Donor Research Living Donor Risks Living Kidney Donor

Understanding Kidney Donors’ Increased Kidney Failure Risk

By now, we’ve all seen the studies stating that living kidney donors have an 8-11x increased risk of kidney failure as compared to their well-matched, two-kidneyed cohort. And you’ve probably seen the transplant industry’s spin on that data, their sputtering “Well, but, the *absolute* risk is still really, really low”

But is it?

Steiner attempts to answer that question, at least some of it, by breaking down the overall risk into its important pieces-parts. He says:

 

“The 1% lifetime post-donation risk in the US study requires medical screening to predict ESRD in 96 of 100 candidates. This is particularly unlikely in the 30–35% of candidates under age 35, half of whose lifetime ESRD will occur after age 64. Many experts have attributed the increased relative risks in these studies to loss of GFR at donation, which ultimately means that high–normal pre-donation GFRs will reduce absolute post-donation risks.”

“Young vs. older age, low vs. high–normal pre-donation GFRs, black race, and an increased relative risk of donation all predict highly variable individual risks, not a single “low” or “1%” risk as these studies suggest.”

A uniform, ethically defensible donor selection protocol would accept older donors with many minor medical abnormalities but protect from donation many currently acceptable younger, black, and/or low GFR candidates.

I encourage everyone to read the whole thing. Your health may depend on it.

 

 

Steiner, R. (2016). Moving closer to understanding the risks of living kidney donation Clinical Transplantation, 30 (1), 10-16 DOI: 10.1111/ctr.12652

Categories
Follow-Up Living Donor Research Living Donor Risks Living Kidney Donor

Surgical Complications of Living Kidney Donation

WARNING: It’s imperative to remember that during the years of this analysis (2008-2012), more than 1/3 of living kidney donors were reported “lost” to follow-up. Many living donors with post-donation problems have reported that their transplant center denied their symptoms were related to the donation, and refused to treat them. It’s not a stretch to assume these same centers never reported those symptoms to OPTN as they were required to do. It’s best to assume the numbers below are *under*estimates of the true incidence of donation surgical complications.

 

“Overall, 16.8% of donors experienced a perioperative complication, most commonly gastrointestinal (4.4%), bleeding (3.0%), respiratory (2.5%), surgical/anesthesia-related injuries (2.4%), and “other” complications (6.6%)”

African Americans had increased risk of any complication.

Other significant correlates of Clavien grade IV or higher events included obesity, predonation hematologic and psychiatric conditions, and robotic nephrectomy

Annual center volume >50 was associated with lower risk.
Ak?nc?, S. (2016). Re: Perioperative Complications after Living Kidney Donation: A National Study Journal of Urological Surgery, 3 (3), 103-103 DOI: 10.4274/jus.2016.03.023

Categories
Living Donor Research Living Donor Risks Living Kidney Donor

Male and BMI higher risk 5 years post-donation

A single center analysis of 77 living kidney donors 5 or more year post-donation has found that men and those with high BMI are at higher risk of low GFR (kidney function < 60), hypertension, and proteinuria; all symptoms of eventual kidney failure.

Unfortunately, I couldn’t access the complete article, so I don’t know if there’s a correlation between pre-donation levels and this post-donation result. However, it’s been previously established that folks with high BMI may already be hyperfiltrating pre-donation, which means their capacity for “compensation” post-donation is already maximized. So, this result just adds to that literature.
Bello, R., Bello, V., Rosa, T., Junqueira, L., Freitas, E., & Veiga, J. (2015). Male Gender and Body Mass Index Are Associated With Hypertension and Reduced Kidney Function 5 or More Years After Living Kidney Donation Transplantation Proceedings, 47 (10), 2816-2821 DOI: 10.1016/j.transproceed.2015.10.041