Living Donor Research Living Donor Risks Living Kidney Donor

Gout in Living Kidney Donors

A recent study indicates that living kidney donors are at a higher risk of gout than non-donors.

” Gout developed in significantly more donors than non-donors (3.4% vs. 2.0%), a difference that translated into a 60% increased risk of gout among living donors”

This appears to be due to living kidney donors’ higher serum uric acid concentration.


A new analysis reveals that “By seven years [post-donation], African Americans were almost twice as likely to develop gout as Caucasian donors (4.4 vs. 2.4%; adjusted hazard ratio, aHR, 1.8; 95% confidence interval (CI) 1.0-3.2). Post-donation gout risk also increased with older age at donation (aHR per year 1.05) and was higher in men (aHR 2.80).”


“Compared to matched donors without gout, donors with gout had more frequent renal diagnoses, reaching significance for acute kidney failure (rate ratio 12.5; 95% CI 1.5-107.0), chronic kidney disease (rate ratio 5.0; 95% CI 2.1-11.7), and other disorders of the kidney (rate ratio 2.2; 95% CI 1.2-4.2)”




Lam N.N., Garg A.X., Segev D.L., Schnitzler M.A., Xiao H., Axelrod D., Brennan D.C., Kasiske B.L., Tuttle-Newhall J.E., & Lentine K.L. (2015).
Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications American Journal of Nephrology, 14 (3), 231-240

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