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Living Donor Research Living Donor Risks Living Kidney Donor

Gout in Living Kidney Donors

A recent study indicates that living kidney donors are at a higher risk of gout than non-donors.

” Gout developed in significantly more donors than non-donors (3.4% vs. 2.0%), a difference that translated into a 60% increased risk of gout among living donors”

This appears to be due to living kidney donors’ higher serum uric acid concentration.

 

A new analysis reveals that “By seven years [post-donation], African Americans were almost twice as likely to develop gout as Caucasian donors (4.4 vs. 2.4%; adjusted hazard ratio, aHR, 1.8; 95% confidence interval (CI) 1.0-3.2). Post-donation gout risk also increased with older age at donation (aHR per year 1.05) and was higher in men (aHR 2.80).”

And:

“Compared to matched donors without gout, donors with gout had more frequent renal diagnoses, reaching significance for acute kidney failure (rate ratio 12.5; 95% CI 1.5-107.0), chronic kidney disease (rate ratio 5.0; 95% CI 2.1-11.7), and other disorders of the kidney (rate ratio 2.2; 95% CI 1.2-4.2)”

 

 

 

 
Lam N.N., Garg A.X., Segev D.L., Schnitzler M.A., Xiao H., Axelrod D., Brennan D.C., Kasiske B.L., Tuttle-Newhall J.E., & Lentine K.L. (2015).
Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications American Journal of Nephrology, 14 (3), 231-240

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