Living Donor Research

Importance of HLA-B matching

Sepsis remains one of the most common causes of death among renal transplant recipients.

A retrospective analysis was performed of all adult renal transplant recipients at our single transplant center transplanted between January 1, 2001, and December 31, 2010. 105 (10.4%) of 1013 patients studied were diagnosed with sepsis, among which 31 patients (29.5%) developed severe sepsis or septic shock, and 28 patients (26.7%) died from sepsis.

The highest incidence of sepsis, 31.4%, was in renal transplant recipients with diabetes and zero HLA-B matches. Five-year patient survival was 70.3% with sepsis compared with 88.7% without (p=0.001).

Among patients developing sepsis after renal transplantation age, body mass index >30 or <17.5 kg/m2, and zero HLA-B matches were predictive factors of mortality.

The highest mortality in renal transplant recipients developing sepsis, 77.8%, was observed in patients with zero HLA-B matches and body mass index >30 or <17.5kg/m2. Five-year patient survival with sepsis was 79.2% with one or two HLA-B matches versus 55.2% with zero HLA-B matches (p=0.03). Full abstract:

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