Living Donor Risks

Low Kidney Function Associated With Cognitive Impairment

“Chronic kidney disease (CKD) has a well-established association with impairment on neurocognitive tests, particularly measures of frontal/executive function”

“MCI [Mild Cognitive Impairment] is a transitional state between normative cognitive aging and dementia. MCI is  often divided into amnestic (aMCI) form, with reduced memory performance and nonamnestic forms (naMCI), with reduced performance in cognitive domains other than memory”

I bolded the phrase because the study subjects were 70 years old and above. It’s easy to think “Eh, old people are all batty” but this study is specifically looking at cognitive impairment beyond that of normal aging. Besides, we living kidney donors hope to make to 70, right?


“The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m2 units) was classified into low (<45), moderate (45–59), and high (>60).”


“Low eGFR was independently associated with dMCI and aMCI in fully adjusted models.”

“At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.”


Full study available here:

Zammit, A., Katz, M., Zimmerman, M., Bitzer, M., & Lipton, R. (2015). Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring DOI: 10.1016/j.dadm.2014.12.002

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